Field research was conducted in 1996 to evaluate the utility of Roundup Ready® cotton (Gossypium hirsutum L.) for weed management systems in Georgia. Small plots were established at the Plant Sciences Farm near Athens, GA. A tillage experiment with weed management systems with glyphosate (Roundup®) alone or in sequence with a residual broadleaf or residual grass herbicide was examined in either conventional- or conservation-tillage cotton and a systems experiment in which weed management systems utilizing glyphosate were compared to several standard residual grass and broadleaf herbicides were initiated. Roundup Ready® cotton showed no differences in germination, vigor, emergence, or cut-out when compared to non-transgenic cotton. Glyphosate did not injury cotton at any application timing and differences in yield were due to weed management. Weed control for all weed management systems including glyphosate was good (>80% control at 84 days after planting). Norflurazon plus fluometuron or pyrithiobac plus fluometuron followed by one application of glyphosate provided the best weed control, seed cotton yield, and greatest yield return on herbicide dollar spent of the postemergence systems examined..