Five field experiments were conducted over 2 years (1995 and 1996) at two locations to evaluate the need for soil-applied residual herbicides in weed management programs for Roundup Ready^TM cotton. At four of the five locations, adequate early-season weed control was achieved with single or sequential postemergence applications of Roundup (glyphosate) with Prowl (pendimethilin) preplant-incorporated (PPI) @ 0.75 lb ai/ac or Cotoran (fluometuron) applied preemrgence (PRE) @ 1.2 lb ai/ac. Seed cotton yields were higher when soil-applied herbicides were included. At another location, adequate weed control and maximum cotton yields was attained with a single postemergence application of Roundup Ultra with no soil-applied herbicide. This was attributed to low weed seed germination during the season due to drought conditions.