Field research was conducted in 1995 and 1996 on the Monsanto Delta Research Farm in Proctor, AR to evaluate the usefulness of preplant incorporated (PPI) and preemergence (PRE) herbicides in weed control systems using Roundup^® herbicide (glyphosate) in Roundup Ready^® Cotton (Gossypium hirsutum L.). In both years, Roundup alone over-the-top (OT) provided excellent control of annual broadleaf and grass weeds, including morningglory (Ipomoea spp.), velvetleaf (Abutilon theophrasti Medik.), cocklebur (Xanthium strumarium L.), prickly sida (Sida spinosa L.), and large crabgrass [Digitaria sanguinalis (L.) Scop.], 2 to 3 weeks after treatment (WAT). Sequential post-directed (PD) Roundup treatments provided season-long control. Treflan^® (trifluralin) and Cotoran^® (fluometuron), when used, reduced the weed populations early, but enough weeds still existed to warrant a Roundup OT application. Treflan and Cotoran had little affect on late season weed control. There were no significant differences in yields in 1995. In 1996, however, commercial standard treatments yielded significantly lower than most Roundup treatments.