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Smooth Muscle Contractor Activity of Cotton Dust Aqueous Extract In Vitro: II - The Response of the Guinea Pig Trachea in the Absence of 5-HT Induced Mechanisms is Only Partly Mediated Through Histamine-Sensitive Receptors

B. Riazi-Farzad, P.J. Nicholls, R.D.E. Sewell


Using isolated guinea pig trachea that was relatively insensitive to 5-HT, it was shown that, in the absence of 5-HT induced mechanisms, the response to cotton dust aqueous extract (CDE) was only partially (75%) blocked by the antihistamine, chlorpheniramine at concentrations that completely blocked histamine. Methysergide also blocked the CDE-induced response (90%). Given that this preparation is insensitive to 5-HT, the mechanism of action of methysergide is unclear. Other studies have identified actions of methysergide unrelated to 5-HT, including interference with the action of eicosanoids. When the trachea was superfused, dose-dependent responses could be obtained with carbachol but not with CDE.

Reprinted from Proceedings of the 1996 Beltwide Cotton Conferences pp. 343 - 346
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998