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Smooth Muscle Contractor Activity of Cotton Dust Aqueous Extract In Vitro: I - Part of the Cotton-Dust-Aqueous-Extract- Induced Contraction of the Isolated Rat Fundus Strip is not Due to Endogenous 5-HT or 5-HT Release Mechanisms

B. Riazi-Farzad, P.J.Nicholls, R.D.E. Sewell


Endogenous 5-HT has been proposed as the mediator responsible for cotton dust aqueous extract (CDE)-induced contraction of the isolated rat stomach fundus. It has been previously reported that there is a residual response to CDE in the presence of concentrations of methysergide which completely block the responses to 5-HT. This study confirms the finding and shows that a combination of the cyclooxygenase inhibitor, indomethacin, and the non-selective leukotriene antagonist, FPL55712, (at concentrations which individually do not affect 5-HT or CDE-induced contractility) in combination, significantly blocked CDE-induced contractions (38%) but not those to 5-HT. Whilst the latter results cannot be readily explained, they clearly show that part of the response is not due to 5-HT or 5-HT release mechanisms.

Reprinted from Proceedings of the 1996 Beltwide Cotton Conferences pp. 336 - 342
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998