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Smooth Muscle Contractor Activity of Cotton Dust Aqueous Extract In Vitro: III - Fractionation Suggests that Different Components are Responsible for the Contractions Induced in the Rat Stomach Fundus and the Guinea Pig Trachea

B. Riazi-Farzad, P.J. Nicholls, R.D.E. Sewell


A number of studies have shown that aqueous extracts of cotton dust cause contraction of a variety of smooth muscle preparations. Accordingly, it has been postulated that there is a "smooth muscle contractor agent" in cotton dust. Using solvent extraction techniques, this study provides evidence that there are at least two rat fundus contractor agents neither of which fits the profile of activity observed in the isotonic guinea pig isolated trachea preparation.

Reprinted from Proceedings of the 1996 Beltwide Cotton Conferences pp. 346 - 349
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998