Effects of tillage practices, row spacings, and application of the growth regulator Pix^® on cotton lint yields were evaluated in a three-year field study conducted in West Tennessee. Average yields produced in 30- and 40-inch row spacings were similar during the period 1992 through 1994. However, in any given year, effectiveness of a particular row spacing appeared to be dependent upon the nature of the growing season. No-tillage production practices consistently resulted in higher lint yields than planting into a conventionally prepared seedbed. In particular, the yield advantage of no-tillage averaged 73 pounds of lint per acre over the life of the study. Application of Pix^® consistently resulted in significantly increased yields, the average yield advantage over three years being 93 pounds of lint per acre. The magnitude of the yield advantage associated with applying Pix^® was influenced by the nature of the production year. Further, the positive effect of Pix^® application was more pronounced in plots planted with 40-inch row spacing than in plots planted in 30-inch rows.