Upper Egypt. The results obtained from Trial A showed that non of the crosses could exceeded the check variety Giza 80 in both yield and its contributing variables, while 4 crosses were promising to their performances for yield and its contributing variables in Trials B. These crosses were G. 83 x Dendera, Giza 83 (Giza 72 x Dendera), radiated Ashmouni 302 x Giza 83 and Giza 83 x G. 80. The heritability values, and the highly significant genotypes x locations interaction indicated that, the studied crosses were affected by the environment and it should be evaluated for several years at different locations. Genetic gains at 5% intensity of selection were 13.37% for A and 7.24% for B, 4.89% for A and 2.7% for B, 9.15% for A and B 8.08% for seed cotton yield, weight of 50 bolls and earliness index, respectively. Genetic coefficient of variability value was higher for seed cotton yield in Trial A (8.19), while this value was intermediate for other characters in both traits (A) and (B).