Field experiments were established at the Calhoun Research Facility, Clemson, SC to compare the response of fifteen broadleaf weed species to DPX-PE350 (Staple), bromoxynil (Buctril), and glyphosate (Roundup) and to examine the effect of growth stage on weed responses. Weeds were planted 1, 12, and 23 July 1993 in one row plots, 1 m long, arranged in a randomized complete block design with three replications. Weeds used were coffee senna, common cocklebur, cowpea, Florida beggarweed, hemp sesbania, Palmer amaranth, prickly sida, ivyleaf morningglory, entireleaf morningglory, pitted morningglory, smallflower morningglory, sicklepod, smooth pigweed, tumble pigweed, and velvetleaf. The experiment was irrigated as needed. Percent control ratings are based on the second and third plantings (weeds averaging 5 inches). Buctril (.38 and .75 lb ai/ac), Roundup (.5 and 1.0 lb ai/ac), and Staple (.0313 and .0625 lb ai/ac) were applied using a CO(2 )backpack sprayer set to deliver a spray volume of 20 gal/ac at 28 psi. At the time of herbicide application the majority of the weed species were < 4 inches for the third planting date, 2 to 6 inches for the second planting date, and 9 to 18 inches for the first planting date. Herbicides were applied 6 August 1993 (2WAP, 4 WAP, and 6 WAP). Buctril (0.75 lb ai/ac) provided excellent (>90%) control of velvetleaf, cocklebur, coffee senna, pitted morningglory, smooth pigweed, tumble pigweed, and jimsonweed; good (80 to 89%) control of Florida beggarweed, ivyleaf morningglory, and hemp sesbania, and poor to fair (<80%) control of the other five weed species. Staple (0.0625 lb ai/ac) provided excellent control of all pigweed species, coffee senna, Florida beggarweed, hemp sesbania, jimsonweed, ivyleaf morningglory, and smallflower morningglory; good control of velvetleaf, common cocklebur, and pitted morningglory; and poor to fair control of the other three species. Roundup (0.5 lb ai/ac) provided excellent control of all weed species except smallflower morningglory (80%), and pitted morningglory (78%)