The good use of cultural or agronomic practices is fundamental to the production of high yields and quality of American Pima cotton. In order for Pima farmers to maintain viable production operations, a continual review and improvement upon the existing set of cultural practices are in order. Basic aspects of crop production such as planting date management, soil fertility and plant nutrition, plant growth regulator use, crop termination, and defoliation are reviewed in this paper in relation to American Pima cotton production. Specific attention is also given to potassium (K) fertility management and Alternaria leaf spot regarding new aspects of potential management needs.