Both economic and environmental benefits should be directly realized by efficient decisions of the end-of-season management practices in cotton (Gossypium hirsutum L.). To maximize profit and minimize risk associated with poor weather in late season, producers must incorporate crop status and weather conditions when making decisions. The purpose of this study was to generate the decision rules for the end-of-season decisions by integrating the crop-oriented and weather-oriented approaches. The crop-oriented approach is largely based upon fruiting status of the crop. The key in this approach is that five main-stem nodes above the first-position white flower (NAWF=5) have been identified as a signal of cutout and thus define the flowering date of the last effective boll population. Decision rules for timing of defoliation and insecticide termination have been generated based upon the number of heat units (HU) needed to develop this last effective boll population to specific degrees of maturation. The weather-oriented approach reflects the effect of weather conditions on the end-of-season decisions. Thus far, target dates of cutout and harvest completion have been established based upon long-term weather patterns in the Mississippi River Delta region. These target dates provide a supplementary guideline on decisions at the end of season and assist establishing the optimum growth patterns of the crop. Time suitable for field operations per week have been estimated and could be useful for harvest scheduling. The integration of the crop-oriented and weather-oriented approaches should generate a profitable decision-making system for the end-of-season cotton management.