Does Cotton Bract Extract Challenge Cause "Monday" Bronchospasm?

E. Neil Schachter, J. Russomanno, J. Siegel, E. Fine, N. Rienzi, T.J. Witek Jr., M.G. Buck, and J. Godbold


 
ABSTRACT

Byssinosis is an occupational airway disease associated with the inhalation of cotton dust. "Monday dyspnea" has been used to describe the associated symptoms accompanied by objectively measured bronchospasm on the first workday of the work week. Cotton Bract Extract (CBE) is a water soluble extract used to characterize byssinotic responses. We studied the ability of CBE to cause "Monday" bronchospasm. We exposed 27 healthy non-smokers (NS) to CBE inhalation on 5 consecutive days, and on an additional day, Day 8, following a 2 day interruption of CBE inhalation. Partial and maximal expiratory flow volume loops were obtained prior to (BL) and at 15 minute intervals for 2 hrs after CBE inhalation. On a preliminary screening day methacholine responsiveness (MCR) was characterized. MCR was also characterized 2 hours following CBE challenge on Days 1,5 and 8. Longitudinal data analysis, comparing the average maximal MEF40(P) decrement from BL (AMMPDB) from Day 1 with the AMMPDB from each of the subsequent days revealed that the AMMPDB was greater on Day 1 than on Day 2 through Day 5 (p=0.002). No significant difference in AMMPDB was noted between Day 1 and Day 8. No significant difference in AMMPDBs was noted between non-Monday days. In subjects sensitive to CBE (responders), enhanced responsiveness to methacholine was noted on Days 1 and 8, compared to screening Day; MCR on Day 5 was similar to that of the screening Day.



Reprinted from 1993 Proceedings Beltwide Cotton Conferences pp. 279 - 280
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998