Root-knot nematodes and Fusarium wilt have long been recognized as important pathogens of cotton, especially so because of the complex disease syndrome resulting from the interaction of the two pathogens. Much effort has been devoted to, and progress made in, developing cotton cultivars with resistance to Fusarium wilt and to wilt resistance that is effective when plants also are infected by root-knot nematodes. Less progress has been achieved in development of cultivars with similarly high levels of resistance to the nematode. Agronomically superior cotton breeding lines with high levels of resistance to root-knot nematodes recently have been released, however, and cultivars with high levels of resistance to Fusarium wilt and root-knot nematodes should be available in the near future.