Experiments were conducted in 1989 and 1990 to evaluate weed control, cotton yields, fiber quality, and returns as influenced by postemergence directed herbicide combinations. Application of directed herbicides improved control of morningglories, prickly sida, and annual grasses compared to cultivation only or a standard soil-applied herbicide program with cultivation. Use of a directed herbicide resulted in positive returns compared to negative returns from cultivation only or a standard soil-applied program without directed applications of herbicides. There were few differences among directed herbicide combinations in the parameters evaluated. In a different experiment with morningglories only, the addition of MSMA to herbicides labeled for directed application generally improved control compared to the herbicides applied alone. In most instances, the addition of MSMA improved control up to an acceptable level (>70%).