Coker 315 cotton was planted on three farms near the Pee Dee Research and Education Center, Florence, SC. Twelve 0.1-acre plots were planted on each farm, randomly selected, for treatment, and maintained with standard farming practices. Plots selected for full treatment were sprayed as often as needed for complete protection with recommended insecticides from true-leaf stage to fruit maturity, while the other plots were treated as needed, based on scouting reports, or left totally untreated with insecticides. Results indicated excess insecticide applications may increase yields but their use may not be economically justified.