The reniform nematode, Rotylenchulus reniformis has become a serious threat to Mississippi cotton production. High nematode populations, alone and in combination with seedling disease pathogens, have resulted in yield reductions even under optimum growing conditions. A field experiment was conducted in which seven nematicidal compounds (Counter, Mocap, Nemacur, Temik, Thimet, Vydate and an experimental seed treatment, GUS IS 11) were evaluated for control of the reniform nematode. Reniform populations increased in all treatments with a range of 5150 to 18,540 young adults/250cm³ soil. This represents a 200 to 1106 percent population increase during the growing season. Although no chemical treatment significantly reduced the final reniform population counts, final populations recovered from soils of several treatments were lower than the untreated check.