A Morphometric Comparison of Lungs after Aerosol Exposures to Either Aqueous Endotoxin (LPS) Suspensions or Cotton Dust

Robert Burrell and R. Clark Lantz


 
ABSTRACT

Previous studies have been concerned with defining the earliest cellular and mediator responses in the lungs following aerosol exposure to aqueous suspensions of purified bacterial LPS. To determine what part LPS plays in dust exposure, a new study was made comparing the previous data base with that. obtained from animals exposed to cotton dust inhalation adjusted to produce an LPS concentration (4 ug/m3) equal to that used with the aqueous suspensions. Differences in absolute lung volume, airspace volume, inflammatory cells, and interstitial tissue were noted and will be discussed. It was concluded that LPS contributes to the overall pathology initiated by cotton dust, perhaps by enhancing the effects of other materials present, but does not account for all of the changes seen.



Reprinted from Cotton Dust: Proceedings--11th Cotton Dust Research Conference 1987 pg. 36
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998