A typical Mid-South cotton was ginned using minimum, standard and two intermediate levels of cleaning. The cotton was then processed into yarn using typical textile mill procedures except that three different mill cleaning levels were selected to compensate for the reduced cleaning at the gin. Processing results indicate little or no differences in yarn quality for the cleaning conditions studied. However, there were significant differences in waste removal and end breakage rates in spinning. The minimum gin cleaning conditions resulted in significantly higher waste removal in the mill that probably would require increased equipment capacity. However, the intermediate gin cleaning condition using one lint cleaner resulted in waste removal that can likely be accommodated without mill waste handling equipment changes and also provides significant improvement in mill processing quality. Under current marketing conditions use of one lint cleaner provides maximum return to producers and an estimated 10 percent increase in productivity at lower cotton costs for textile mills.