Experiments were conducted at the Southwest Georgia Branch Experiment Station near Plains and the Plant Science Farm near Athens to evaluate new chemistries for post-directed weed control in conventional and Roundup Ready cotton. Glyphosate was applied broadcast to the test area at the 2-leaf stage and directed at the 6” stage of cotton. Flumioxazin, sulfosulfuron, diclosulam, halosulfuron, cloransulam, trifloxysulfuron (CGA 342622), rimsulfuron, flufenapyr, carfentrazone, mesotrione, and diuron were compared or cotton injury and weed control when applied to cotton at the 14-16” stage post- directed. Sulfosulfuron and rimsulfuron caused greater than 25% cotton injury so probably would not be suitable for post- directed weed control in cotton because of excessive crop injury. The other herbicides caused less than 15% cotton injury 14 days after treatment (DAT). All of the herbicides examined provided >95% Palmer amaranth (Amaranthus palmeri) control 30 DAT. Cloransulam, trifloxysulfuron, flufenapyr, flumioxazin, and diuron provided sicklepod (Senna obtusifolia) control were similar whereas halosulfuron and carfentrazone provided less weed control.