Lint yield improvements were observed but varied when Bollgard™ varieties received broad spectrum insecticide applications made according to: a.) thresholds being met for either primary or secondary pest infestations, and b.) when crop fruiting patterns were vulnerable to injury from a multi-pest complex which included plant bugs, stink bugs, and lepidopterous insects. Pyrethroids alone or in combination with imidacloprid were used as overspray treatments and were applied as single sprays or as sequential sprays during the months of June, July, and August. Results for 1999 and 2000 indicated that a single application made during early August preserved yield to a greater degree than all other treatment regimes including sequential treatments where an August application was included. This trend was not observed in 2001 with only a relatively modest yield difference detected among insecticide overspray treatments. During this three year study, average yields were increased in a range from 110 to 352 pounds per acre depending upon the insecticide treatment regime. These overspray trials have demonstrated that Bollgard cotton has even a greater yield potential when secondary pests (plant bugs, stink bugs and boll weevils) and to a lesser extent primary pests (Heliothine complex) are managed relative to their overall injury potential.