A study was initiated in 1999 and repeated in 2000 and 2001 to evaluate a Bollgard^® II cotton for caterpillar pest control in comparison with two Bollgard^® cottons and a conventional non-transgenic Bt cotton. Cotton varieties were tested under caterpillar insecticide regimens that were sprayed or unsprayed. Effects on both targeted lepidopteran pests and certain non- targeted sucking insect pests were evaluated. Only 2001 data are presented because of low infestation levels of insect pests in 1999 and 2000. Bollgard^® II provided excellent control of bollworm, tobacco budworm, beet armyworm, cabbage looper, and saltmarsh caterpillar. There was little indication of varietal differences in susceptibility to tarnished plant bug, stink bug, cotton aphid, and whitefly. On one observation date, there were significantly more whiteflies (predominantly bandedwinged whitefly) in the conventional variety, Deltapine 5415, than in the Bollgard^® and Bollgard^® II varieties.