In 2001, more than 15,000 bollworm moths and 4000 budworm moths were bioassayed. Survival values for bollworm moths at the 5 µg/vial concentration and 10 µg/vial concentration of cypermethrin were similar to survival values recorded during the 2000 season. Six sites had greater than 10% survival during at least one month at the 10 µg/vial concentration and 11 sites had greater than 5 % survival. This represented a 1.2-fold increase compared to data collected during the 2000 season, a 2-fold increase compared to data collected during the 1999 season and a 6-fold increase compared to data collected during the 1998 season. Survival at the 10 µg/vial concentration of cypermethrin ranged from a low of 0% to a high of 50%. As expected, survival values for tobacco budworm adults at the 10 µg/vial concentration of cypermethrin were high throughout the mid-south/southeastern test areas. All eighteen test sites had greater than 10% survival; eight of eighteen sites had greater than 50% survival; and two of eighteen test sites had greater than 70% survival. Survival at the 10 µg/vial concentration of cypermethrin ranged from a low of 12% to a high of 76%. Survival of bollworm adults at a 15 µg/vial concentration of spinosad ranged from a low of 0% to a high of 57%. Eight of 33 sites evaluated had greater than 20% survival; three of 33 sites evaluated had greater than 50% survival. Tobacco budworm adults were less tolerant of spinosad treatment. Survival of tobacco budworm adults at a 15 µg/vial concentration of spinosad ranged from a low of 0% to a high of 24.4%. Only five of 19 sites evaluated had greater than 10% survival, and only one of 19 sites evaluated had greater than 20% survival. These data suggest that bollworm populations throughout the mid-south/southeastern U.S. are developing resistance to the pyrethroid insecticides; resistance to pyrethroids in tobacco budworm populations is widespread; and efforts to monitor pyrethroid resistance and the effects of spinosad in bollworm populations should remain a priority for the development and implementation of future resistance management strategies.