Twenty-five pairs of pheromone-baited wire cone traps representing 12 parishes in Louisiana were used to survey insecticide susceptibility of tobacco budworm and bollworm from May to Sep during 2001. Percent survival (10µg/vial cypermethrin in AVT) of tobacco budworm moths ranged from 47% to 76%, with a mean survival of 59%. Percent survival (5µg/vial cypermethrin in AVT) for bollworm moths ranged from 6% to 32%, with a mean survival of 21%. No field control failures of bollworm with pyrethroids were reported in Louisiana during 2001. Susceptibility of tobacco budworm and bollworm to spinosad also was monitored using the AVT (5µg/vial and 15µg/vial concentrations). Tobacco budworm survival ranged from 4% to 16% and 0% to 19% for the 5µg/vial and 15µg/vial concentrations, respectively. Higher than expected survival (31%-56% at 15µg/vial) of male tobacco budworm moths was observed at several locations in Northeast Louisiana. Bollworm survival ranged from 0% to 40% and 0% to 28% for the 5µg/vial and 15µg/vial concentrations, respectively. Suspected field control failures of infestations of tobacco budworm larvae following applications of Tracer 4SC (spinosad) were reported in Northeast Louisiana during 2001. These problems coincided with locations where high survival of male tobacco budworm moths to spinosad in the AVT was observed. Laboratory testing of collections from these areas indicate elevated LD₅₀ and LD₉₀ values and changes in slopes of log-dose probit lines compared to reference colonies.