The objective of this work was to evaluate the performance of thiamethoxam, in different dosagens, formulations and application strategies, aiming the aphid management and the reduction of foliar applications in cotton. Two experiments were deployed, the first in the 98/99 season and the second in the 99/00 season, both in the Brazilian cerrado, and with the cotton cultivar Delta Pine Ita-90. The design was of randomized blocks, with 8 treatments and 4 replications. Plot size was 12 rows by 15m length (162m ² ). In the first experiment the treatments consisted of: thiamethoxam (Cruiser 700 WS) applied as a seed treatment at the dose of 300 g c.p./100 kg of seeds + thiamethoxam (Actara 10 GR), applied at covering (granulated) at the doses of 15 and 20 kg c.p./ha, 35 and 45 days after planting; thiamethoxam (Actara 10 GR), at the doses of 15 and 20 kg c.p./ha and aldicarb (Temik 150) at 8kg p.c. /ha, applied in-furrow. In the second experiment the treatments consisted of: thiamethoxam (Cruiser 700 WS) applied as a seed treatment at the dose of 300 g c.p./100 kg of seeds + thiamethoxam (Actara 10 GR), applied at covering (granulated) at the dose of 20 kg c.p./ha, in different times for each treatment (at 10, 15, 20 and 30 days after planting); thiamethoxam (Actara 10 GR), at the dose of 20 kg c.p./ha, aldicarb (Temik 150) at 8 kg c.p./ha, applied in-furrow and imidacloprid (Gaucho 700 PM) applied as a seed treatment at 500 g c.p./100 kg + carbosulfan (Marshal 200) in foliar applications at 10-day interval, at dose of 600 ml c.p./ha. Results showed that the combination: seed treatment + application of granulated at covering was efficient for the control of the cotton aphid, and it reduced the number of diseased plants and it provided increment in the productivity in relation to the control treatment, being viable as a part of the cotton aphid management, as a replacement to sequential foliar applications.