A field study was initiated in 1997 to evaluate the response of cotton (Gossypium hirsutum) to varying rates of irrigation and fertility. The test was conducted on a Decatur silt loam (Rhodic Paleudult) in North Alabama. Irrigation scheduling was based on the MOISTCOT (Moisture Management and Irrigation Scheduling for Cotton). Four irrigation regime capabilities consisted of: no irrigation, irrigation on demand, 1-inch water wk^-1, and 2 inches water wk^-1. Fertility treatments included preplant and sidedress applications of N. Two foliar treatments (4.4 lbs K ac^-1 plus 5 lbs N ac^-1 or 4.4 lbs K ac^-1) were applied four times, beginning one week after first white bloom. In 1997, irrigation and the interaction between irrigation and fertility treatments affected seed cotton yields. In 1998, significant differences arose from irrigation treatments, fertility treatments, and the interaction between irrigation and fertility treatments. In the standard nitrogen fertility treatments, applying 1-inch water wk^-1 increased seed cotton yields by an average of 1546 lbs ac^-1 as compared to the non-irrigated treatment. Irrigation on demand resulted in a slight reduction in seed cotton yield.