The low rate of in-furrow granular application of pentachloronitrobenzene (PCNB) and etridiazole combined with Bacillus spp. at 5.5 lb/A improved seedling stand, less skippy, promoted early bloom set and boll set based on percent open bolls, and increased seed cotton yield. The high rate of PCNB/etridiazole/Bacillus spp. applied at 7.4 lb/A increased seedling vigor and reduced severity of root rot. The low rate of application of azoxystrobin (5.6 fl oz/A) increased root weight. A beneficial compatible relationship between PCNB-etridiazole and Bacillus spp. was demonstrated by controlling Pythium spp.