Conservation tillage cotton production has increased in recent years in south Texas but a major factor which prevents producers from adopting conservation tillage practices is the perceived lack of adequate weed control systems. A two year study was conducted on both corn and grain sorghum stubble to evaluate weed control in cotton planted without tillage into corn residue which exceeded 10,000 kg ha-1 and grain sorghum stubble which exceeded 6,000 kg ha-1. Sixteen weed management treatments were evaluated for crop injury, control of Amaranthus Palmeri and Panicum Texanum. Single herbicide treatments did not provide acceptable weed control of both broadleaf and grass weed weed species. Several combinations of herbicide provided season long control of weeds and did not adversely cotton lint yield. These cotton herbicide combinations included pendimethalin plus fluometuron, clomazone plus pyrithiobac, pendimethalin plus pyrithiobac, fluometuron plus pytithiobac, and pendimethalin pllus fluometuron plus pyrithiobac.