As herbicide-resistant crops enable new choices for cotton weed management, questions remain as to which weed control systems are best suited to different weed populations and tillage practices. Studies were conducted in 1997 at Clayton and Goldsboro, NC to evaluate Staple, Buctril, and Roundup Ultra systems in conventional and no-till production. Cotton varieties included Stoneville 474, Stoneville BXN47, and Paymaster 1330RR. Herbicides included: Treflan PPI at 1 pint/A, Prowl PRE at 1 pint/A, Cotoran PRE or EPDS at 1 quart/A, Bueno 6 EPOST at 1 pint/A, Staple EPOST at 1.2 ounces/A, Buctril EPOST at 1 pint/A, Roundup Ultra EPOST at 1.5 pints/A, Buctril As Needed at 1 pint/A, Roundup Ultra As Needed at 1.5 pints/A, and Bladex + Bueno 6 LAYBY at 0.8 quarts/A and 1.3 quarts/A, respectively. These herbicides were applied in various combinations and mixes depending on variety and tillage practice.