Field experiments were conducted in 1997 at the Blackbelt Research Station near Brooksville, MS to evaluate the use of Staple (pyrithiobac) with Buctril (bromoxynil) or Roundup Ultra (glyphosate) in BXN and Roundup Ready cotton, respectively. Treatments in the BXN experiment were arranged as a two factor factorial in a RCB design with 4 replications. Factor A consisted of a preemergence application of 1.5 lbs ai/A Meturon (fluometuron) or 1.5 lb/A Meturon tank-mixed with 0.5 oz ai/A Staple. Factor B consisted of the following four postemergence treatments: 1.0 oz/A Staple; 1.0 oz/A Staple followed by (fb) 0.5 lbs ai/A Buctril (bromoxynil); 0.5 oz/A Staple tank-mixed with 0.5 lbs/A Buctril; and 0.75 lbs/A Buctril followed by (fb) 0.75 lbs/A Buctril. Common cocklebur (Xanthium strumarium), entireleaf morningglory (Ipomoea hederacea), and prickly sida (Sida spinosa) control did not differ between preemergence treatments and no interaction occurred between the PRE and POST treatments. Late season common cocklebur control was maximized at 82% with the Staple fb Buctril or by the Staple tank-mixed with Buctril. Entireleaf morningglory and prickly sida control ranged from 89 to 95% and 89 to 92% and did not differ among postemergence treatments. Seed cotton yield was greatest with the Buctril tank-mixture or sequential with Staple (1401 to 1525 lb/A) as compared to Staple alone or sequential applications of Buctril which yielded 1190 to 1192 lbs/A.