The main objective of the present work is to study the effect of Monoethanolamine (MEA) (0.04%) as a chemical mutagen on some economic traits. Data showed that (MEA) treatment increased significantly means of boll weight and seed index of the first parent, fiber strength of the second parent and both parents for lint index. Significant positive inbreeding depression was observed for boll weight, seed index, lint index and fiber strength. Epistatic effects were positive and significant in E₁ and E₂ for number of bolls per plant and seed cotton yield.