At-plant and post-plant nematicides were evaluated in three locations over north Alabama for their effectiveness in managing reniform nematodes in heavily infested cotton fields. Both the Temik at-plant rates and the post-plant Vydate and Temik treatments produced profitable yield increases in two of the three field trials. Heavy boll worm and Verticillium wilt in the Jennings field trial nullified any potential yield increases that nematicides may have produced. While Vydate post-plant performed well in two field trials, it is believed to have been instrumental in flaring boll worms in the Jennings field trial. More tests must be conducted to determined if Vydate will fit in the nematicide program for reniform nematodes.