Weed management systems comprised of various soil-applied and postemergence herbicide options were evaluated in 15 trials over a 2-year period (1995 and 1996) in five southeastern states. Systems that included soil-applied and postemergence treatments provided better broad-spectrum weed control and resulted in greater lint cotton yields than soil-applied or postemergence herbicides alone. Greatest cotton injury was observed with Command (clomazone) compared to other soil-applied herbicides. Best broad-spectrum weed control was observed with combinations of Zorial (norflurazon) or Command plus Cotoran (fluometuron) compared to Zorial or Cotoran alone.