Prior to 1995, cotton was the only major agronomic crop in the U.S. without a true POST-over-the top herbicide for annual broadleaf weed control that did not adversely impact crop yield and/or maturity. A registration for Staple and advances in biotechnology led to the registration of Buctril for selective postemergence (POST) weed control in BXN cotton. Roundup Ready cotton will likely receive registration within the next 18 months. Consequently, cotton producers have several different options for POST control of annual broadleaf weeds. The following summarizes research experiences with these three new herbicides over the past four years.