Field studies at four locations in North Carolina and Georgia evaluated Buctril and Cotoran systems for weed control, cotton injury, and yield in reduced and no-till BXN cotton. The herbicide systems evaluated consisted of a factorial arrangement (all possible combinations) of two PRE options, two EPOST options, two POST options, and two LAYBY options. The PRE treatment options consisted of a) Gramoxone Extra at 0.25 lb ai/ac, and b) Gramoxone + Cotoran at 1.5 lb ai/ac. The EPOST treatment options consisted of a) Buctril at 0.375 lb ai/ac, and b) Buctril + MSMA at 1.0 lb ai/ac. The POST treatment options consisted of a) no POST application, and b) Buctril at 0.375 lb/ac. The LAYBY treatment options consisted of a) no LAYBY application, and b) Bladex at 0.8 lb ai/ac + MSMA at 1.0 lb/ac. Additional treatments consisted of Gramoxone Extra or Gramoxone Extra + Cotoran PRE alone or fb Cotoran at 1.0 lb/ac + MSMA at 1.0 lb/ac post-directed (PDS) or fb Cotoran + MSMA PDS fb a Bladex + MSMA LAYBY. A weedy check was also included. All PRE treatments were applied with a NIS at 0.25% (v/v). All treatments were applied with a CO₂ backpack sprayer at 17-20 GPA. Weeds evaluated include redroot pigweed (Amaranthus retroflexus L.), sicklepod [Senna obtusifolia (L.) Irwin and Barneby], and Ipomoea morningglory species (Ipomoea spp. L.). Studies were conducted at Tifton and Calhoun, GA in 1994 and at Clayton and Richfield, NC in 1995. Data represents averages over four locations.