Three field trials, two in Bertie County, NC and one at Tifton, Georgia were conducted in 1994 - 1995 to evaluate Cotoran and Buctril systems for weed control, cotton injury and yield using cotton variety BXN 57. All plots received a blanket treatment of Treflan at 0.75 lb ai / A applied preplant incorporated. Herbicide systems evaluated consisted of a factorial arrangement of PRE, EPOST, POST and LAYBY herbicide treatments. PRE herbicide options consisted of 1) none or 2) Cotoran at 1.5 lb ai / A. EPOST options were 1) none or 2) Buctril at 0.375 lb ai / A or 3) Buctril at 0.375 lb ai / A + MSMA at 0.75 lb ai / A with a NIS at 0.25% v/v. POST options were 1) none or 2) Buctril alone at 0.375 lb ai /A. LAYBY options were 1) none or 2) Bladex at 0.80 lb ai /A plus MSMA at 0.75 lb ai / A with a NIS 0.25% v/v. Treflan PPI alone was considered the broadleaf weed check. Weed control of sicklepod [Senna obtusifolia (L.) Irwin and Barneby], coffee senna (Cassia occidentalis L.), common lambsquarters (Chenopodium album L. ), pitted morningglory (Ipomoea lacunosa L.), prickly sida (Sida spinosa L.), bristly starbur (Acanthospermum hispidum DC.), Florida beggarweed [Desmodium tortuosum (Sw.) DC.], and spurred anoda [Anoda cristata (L.) Schlecht.] were visually assessed 85 - 113 days after treatment depending on the treatment timing and results were averaged across locations.