Field research was conducted in 1995 to evaluate the utility of glyphosate-resistant cotton (Gossypium hirsutum L.) for weed management systems in Georgia. Small plots were established at the Plant Sciences Farm near Athens, GA. Glyphosate was applied at 2-leaf, 5-leaf, and 2-leaf followed by 5-leaf at 0.84 kg/ha cotton with and without soil-applied residual herbicides. Glyphosate-resistant cotton showed no differences in germination, vigor, emergence, or cut-out when compared to non-transgenic cotton. Glyphosate did not injury cotton at any application timing and differences in yield were due to weed management. Glyphosate applied at 2-leaf followed by 5-leaf stage with and without residual herbicides provided weed control equivalent to the standard. Glyphosate applied at 2-leaf stage of cotton without residual herbicide did not provide adequate weed control. Seed cotton yield from all treatments containing glyphosate except for application at 2-leaf cotton without residual herbicides were equivalent to the standard.