Microbial insecticides were tested against Tobacco Budworm, Heliothis virescens, and Beet Armyworm, Spodoptera exigua, in cotton in Prattville, Alabama, summer, 1995. Larval counts and damage by H. virescens were intermediate in number. Several microbial insecticides such as Condor XL, Dipel ES, Gemstar, and AfNPV gave significant reduction in larval and damage counts. Larval counts by Spodoptera exigua were extreme in August. Although Pirate was superior in all five day trials, numberous Bt products and viruses such as Spod-X and AfNPV also gave significant protection compared with the untreated control. These results suggest that microbial control products can reduce damage and larval numbers in cotton.