Postemergence control of broadleaf weeds in bromoxynil (Buctril) - tolerant cotton was evaluated in six experiments conducted in South Carolina from 1991-93. Studies conducted in 1991 and 1992 were destroyed prior to maturity; 1993 tests were harvested for yield. Crop injury (5 to 21% 2 wk after application) occurred in 1991 when Buctril was applied within 1 hr following an application of Poast + crop oil. However, excellent crop tolerance was observed in the five experiments conducted in 1992-93. Buctril provided excellent (> 90%) control of ivyleaf morningglory, tall morningglory, pitted morningglory, common cocklebur, tropic croton, common lambsquarters, and jimsonweed. Prickly sida control ranged from 65% to 100%. Control of sicklepod and Palmer amaranth was not satisfactory. Unacceptable control of Palmer amaranth may be attributable to the time of application. In the 1993 studies where Palmer amaranth control was evaluated, the early postemergence application of Buctril was applied when cotton was 5 inches tall; Palmer amaranth seedlings were up to 13 inches tall at this time. Seed cotton yields in 1993 generally reflected the unacceptable control of Palmer amaranth. Since Palmer amaranth and sicklepod are the first- and sixth-ranked most troublesome weeds in South Carolina cotton, preemergence applications of fluometuron cannot be omitted from weed management programs for bromoxynil-tolerant cotton in many fields. However, Buctril provides adequate control of all other broadleaf species that are common problems in South Carolina cotton.