Reduced tillage cotton is produced on less than 2% of the Georgia cotton acreage. One of the major concerns of producers is achieving acceptable weed control without cultivation. Replicated studies were conducted at Tifton in 1993 to investigate weed management practices necessary for profitable reduced tillage cotton production. Rye was desiccated approximately 1 month prior to planting with Gramoxone Extra at 0.25 lb ai/ac. Preemergence options included 1) Prowl (1.0) applied PRE, 2) Prowl + Gramoxone Extra (0.25), 3) Prowl + Gramoxone Extra + Cotoran (1.5), 4) Prowl + Roundup (1.0), and 5) Prowl + Roundup + Cotoran. Postemergence options included 1) none, 2) MSMA (0.75), 3) Staple (0.063), 4) Staple + MSMA, and 5) Staple + Select (0.094). All herbicides were applied with a nonionic surfactant (0.25% v/v). PRE and POST treatment options were in a factorial arrangement of treatments. Weeds in the test area included common cocklebur, Texas panicum, volunteer peanut, citronmelon, ivyleaf and pitted morningglory, and sicklepod. Cotoran PRE was required for acceptable control of most broadleaf weed species. Roundup PRE was required for good volunteer peanut control. Citronmelon was controlled best with Roundup PRE followed by Staple and/or MSMA POST. Sicklepod control was best with a Cotoran PRE tankmixture followed by MSMA or MSMA + Staple POST. Texas panicum control was best with Select + Staple POST. Pitted and entireleaf morningglory, and common cocklebur control was best with Cotoran PRE followed by Staple or a Staple tankmixture POST.