The postemergence use of graminicides has been an important weed management tool in cotton for many years. Broadleaf weed control in cotton has been managed using mechanical tillage, preplant or preemergence herbicides and in parts of the cotton belt, post-directed herbicide applications. Postemergence broadleaf weed control in cotton has previously been very limited due to unacceptable cotton tolerance with existing postemergence cotton herbicides. DPX-PE350 (formerly KIH-8921) is being developed under the trademark Staple^® for postemergence control of broadleaf weeds in cotton. Clethodim, a new graminicide for use in cotton has shown good activity on both annual and perennial grasses with no phytotoxicity to cotton. The tank mix combination of clethodim (0.094 - 0.124 lb/A) plus DPX-PE350 (0.063 lbai/A) evaluated in cotton field trials has shown excellent activity against annual broadleaf weeds and annual grasses, but in some instances has demonstrated antagonism in control of perennial grasses.