Cotton insects are constantly evolving or changing in their susceptibility to insecticides. The class of insecticides applied, and the intensity they are applied at, has a major impact on this evolutionary process. The intense use of the phosphate insecticide, malathion, in the Boll Weevil Eradication Program, impacts most all other cotton insects, either directly or indirectly. Insects that have been negatively affected by the eradication program in Alabama are bollworms, tobacco budworms, aphids, beet armyworms and the beneficial arthropod complex. Most of these pests present greater control problems to the grower during the early years of the eradication program. The species of insect and magnitude of change, due to eradication programs, may vary somewhat from area to area as this program expands across the cotton belt in future years.