Six cotton varieties were evaluated for their performance in five locations throughout Louisiana in fields infested with the reniform nematode. The varieties at all locations were also treated with Temik 15%G at the rate of 3.5-4.0 pounds per acre which is the standard nematode treatment. At planting levels of reniform nematode varied at each site from very low (several hundred per 500 cm³) to 15,000. All varieties supported very high levels of reniform nematode at the time of harvest. Stoneville 311 yielded the highest at four of the five locations. The other five varieties varied as to their ranking by yield at each location. This suggests that variety selection for a specific area of growing conditions may be important if reniform nematode is present.