It has been suggested that ectoparasitoid venoms are required to regulate the nutritive load of host larvae, to support the development of the parasitoid. However, it appears that the role of Catolaccus grandis (Burks) venom is to induce a partial paralysis of 3rd-instar boll weevil larvae, to decrease its motor activity preventing injury to the parasitoid progeny, during the initial phase of the parasitization process. During this work, we were successful in rearing C. grandis (egg to \adult) on non-venomized boll weevil larvae. The hypotheses that, 1). the first instar parasitoid larvae can also induce a paralytic condition on the host, and 2). that this type of parasitoid non-venomized development may be a common event in nature, were discussed here.