Five cropping sequences of grain sorghum and cotton (Gossypium hirsutum cv. DPL-20) were evaluated for the management of the reniform nematode (Rotylenchulus reniformis). Cropping sequences consist of monoculture cotton, monoculture grain sorghum, and alternate year combination of grain sorghum-cotton. Each treatment was planted with and without aldicarb at 1.18 kg ai/ha. Rotylenchulus reniformis population densities were larger at harvest in plots monocultured for two years with cotton compared with grain sorghum-cotton and monocultured grain sorghum plots. Reniform populations at harvest in monoculture cotton, grain sorghum-cotton, and monoculture grain sorghum plots were 7069, 4163, and 252 nematodes/500cm³ soil, respectively. Seed cotton yields were 2,552 and 2,827 kg/ha in the monoculture cotton and grain sorghum-cotton plots, respectively. The addition of grain sorghum in a cotton production system reduced R. reniformis by an average of 832 nematodes/500cm³ soil and improved seed cotton yields 104.1 kg/ha.