After the loss of DBCP researchers quickly provided rates and application techniques for use of EDB for nematode control in cotton. Thus, cotton farmers still had an effective, low-cost nematicide that could be applied at planting without phytotoxicity. With these materials farmers have over the years tended to develop a "chemicals alone" approach to nematode control. Many growers applied these materials as an insurance policy against "possible" nematode damage rather than according to recommendations based on a nematode assay.

With the loss of EDB, nematicides which have potential for nematode control in cotton include 1,3-Dichloropropene (1,3-D), fenamiphos, aldicarb and carbofuran. All of these materials are cleared for nematode control on cotton except carbofuran. When compared with EDB, these materials have some shortcomings: they are more expensive and, with present rates and application techniques, are less effective.

The 1,3-D nematicide must be applied pre-plant unless research can demonstrate an effective rate that can be applied at planting without phytotoxicity. The other chemicals are non-fumigant, or contact materials, which need additional research on rates and application techniques to determine the role they should play in a cotton nematode control program.