Six Low Rate Multiple (LRM) programs using Pix, PGR IV and PHCA were evaluated in foliar applications to South Texas cotton over a four year period. Under irrigated and high rainfall conditions, 4 oz LRMs provided lint increases averaging 9.5 percent over untreated checks. Dryland increases averaged 3.7 percent for ten locations evaluated. Two of the four years were semi-drought conditions. In a parallel 2-year study, Pix 4 oz LRMs averaged an overall 14.4 percent lint increase (105 lbs/ac), and a 3.5 percent increase (21 lbs/ac) under dryland conditions. PGR IV 4 oz LRMs provided a 9.7 percent lint increase (94 lbs/ac) average in three irrigated tests, and an 11.6 percent increase (75 lbs/ac) average for two dryland locations. PHCA provided no lint increases. Increases in lint yields were attributed to larger boll numbers and increased earliness with PGR IV LRMS. Pix increases were associated with larger boll numbers and boll size. Pix 4 oz LRMS increased fiber strength 1.5-2.8 g/tex over the 4-year study period. PGR IV generally did not increase fiber strength unless early, heavy fruiting resulted in earliness.