Pix (mepiquat chloride) is a growth regulator widely used across the cotton belt to promote earliness through the control of excessive vegetative growth and plant height. A simulation model which determines the timing and rate of Pix application was developed and tested at the Texas A&M Research and Extension Center at Corpus Christi. The model uses simulated plant weight and amount of Pix applied to the crop to estimate a plant Pix concentration. The timing of Pix application is determined by monitoring the bio-dilution rate of Pix in the plant. The rate of Pix to be applied is the amount required to increase the concentration within the plant to a pre-determined level. The Pix management strategy proposed in this paper was evaluated at Corpus Christi, Texas, during 1990 and 1991, using cultivars CAB-Cs and DPL-51. Results of this study indicate that Pix can be applied to dryland crops which often experience postapplication stress at low rates in multiple applications without the risk of reducing yield. The data also show that cultivar CAB-CS may be more responsive (more sensitive) to a given level of Pix than cultivar DPL-51. This observation should be taken into account in the management of Pix for stripper type cottons such as CABCS. This study indicates that the timing and rate of Pix application can be determined by monitoring an estimated Pix concentration within the plant. The Pix management approach proposed here recommended reasonable amounts and frequencies of applications. Yield data for both years seem to indicate that maintaining a Pix concentration between 6-12 ppm for DPL-51 and 5-10 ppm for CAB-CS should prove superior for the Lower Coastal Bend Region of the cotton belt.