In Vitro Effects of Aqueous Cotton Dust Extract on Mononuclear Leukocyte Cyclic Adenosine Monophosphate Levels

Carol E. O'Neil, Margaret A. Reed, and Brian T. Butcher


A standard aqueous cotton dust extract (ACDE) stimulated production of cyclic 3',5' monophosphate (cAMP) in human peripheral blood mononuclear leukocytes (MNL). Prostaglandin, E production by platelets or monocytes contaminating the cell preparation did not appear to cause this increase. Further, this response was not due to stimulation of the beta or H(2) receptor; however, desensitization experiments indicated the response was receptor mediated. Possible involvement of elevated cAMP levels in response to cotton dust and receptor desensitization in byssinosis pathogenesis is discussed.

Reprinted from Proceedings of the 1983 Beltwide Cotton Dust Conference pp. 97 - 100
©National Cotton Council, Memphis TN

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Document last modified Sunday, Dec 6 1998