Foliar TRIGGRR, a plant growth regulator containing cytokinin, increased cotton yields an average of 44 lbs lint/A in 83 research trials conducted in nine states over a nine-year period when applied according to recommended regimens. The average yield increase was 23 lbs lint/A when all treatments, including suboptimal regimens, were included in the analysis (115 experiments). In both cases the average yield increase was significant at the p<0.00001 level when analyses of variance were conducted using all available data from individual replicated plots. Yield increases were observed in each of the nine years of testing and in each of three geographical regions across the cotton belt. Yield increases averaged 107 lbs lint/A in 24 distributor-conducted grower trials in seven states over a four-year period. These analyses demonstrate conclusively that Foliar TRIGGRR increases cotton yields and represents a valuable tool to increase grower profits.