The use of PIX to control excessive vegetative growth and to direct the development of a plant type which is more efficient at producing and retaining bolls is commonly practiced in Mississippi. The objective of this study was to evaluate the effect of single and multiple applications of PIX an the lint yield, boll size, lint percent, and plant structure of variety DES 119. A single application of PIX at the rate of either 8 or 16 oz. starting at early bloom and multiple treatments of either 2 or 4 oz. starting at match-head square applied four times at ten day intervals were evaluated at Mississippi State University in 1987 and 1989 and at Stoneville, MS in 1988 and 1989. Plant mapping information was collected for the Mississippi State University location only.